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Pregnancy Category C
Mechanism of action
Bactericidal; interferes with DNA replication in susceptible
gram-negative bacteria preventing cell reproduction.
For the treatment of infections caused by susceptible gram-negative
bacteria, including E. coli, P. mirabilis, K. pneumoniae, Enterobacter
cloacae, P. vulgaris, P. rettgeri, M. morganii, P. aeruginosa,
Citrobacter freundii, S. aureus, S. epidermidis, group D streptococci
Unlabeled use: effective in patients with cystic fibrosis who have
- The presence of allergy to ciprofloxacin, norfloxacin,
Use caution in the presence of renal dysfunction, seizures.
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- CNS: Headache, dizziness,
insomnia, fatigue, somnolence, depression, blurred vision
- GI: Nausea, vomiting, dry
mouth, diarrhea, abdominal pain
- Hematologic: Elevated BUN,
SGOT, SGPT, serum creatinine and alkaline phosphatase; decreased WBC,
neutrophil count, hematocrit
- Other: Fever, rash