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Back to Infections Drug Index
Name: Clotrimazole
Pregnancy Category C (troche)
Pregnancy Category B (topical, vaginal)
Drug classes
Therapeutic actions
Fungicidal and fungistatic: binds to fungal cell membrane with a
resultant
change in membrane permeability, allowing leakage of intracellular
components, causing cell death.
Indications
- Treatment of oropharyngeal candidiasis (troche)
- Local treatment of vulvovaginal candidiasis (moniliasis; vaginal
preparations)
- Topical treatment of tinea pedia, tinea cruris, tinea corporis due to
Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton
floccosum, Microsporum canis; candidiasis due to Candida albicans;
tinea
versicolor due to Microsporum furfur (topical preparations)
Contraindications/cautions
Allergy to clotrimazole or components used in preparation
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Adverse effects Troche
- GI: Nausea, vomiting, abnormal liver function tests
Vaginal
- GI: Lower abdominal cramps, bloating
- GU: Slight urinary frequency; burning or irritation in the sexual
partner
- Dermatologic: Skin rash
Topical
- Local: Erythema, stinging, blistering, peeling, edema, pruritus,
urticaria, general skin irritation
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