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Back to Infections Drug Index
Brand Name: Fungulin
Name: Amphotericin B
Pregnancy Category B
Drug classes of Fungulin
Therapeutic actions of Fungulin
As with other polyene antifungals, amphotericin B associates with
ergosterol, a membrane chemical of fungi, forming a pore that leads
to K+ leakage and fungal cell death. Recently, however, researchers
found evidence that pore formation is not necessarily linked to cell
death (i.e. Angewandte Chemie Int. Ed. Engl. 2004). The actual
mechanism of action may be more complex and multi-faceted.
Indications of Fungulin
Fungulin is an oral preparations of amphotericin B.
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Main indication is in oral
thrush.
Contraindications/cautions of Fungulin
Hypersensitivity to amphotericin or any component of the
forumulation.
Avoid other nephrotoxic drugs or adminstration when BUN and serum
creatinine, postassium and magnesium levels are elevated. Monitor
renal function tests every 2-4 days or daily if at risk of
nephrotoxicity.
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Adverse effects
of Fungulin
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Side-effects can be severe; nephrotoxicity (kidney
damage) is a major issue. Other side-effects include headache,
vomiting, convulsions and fever; it has to be withdrawn occasionally
from patients to determine whether their fever is due to
amphotericin B or an actual infection. A similar problem exists with
cytarabine.
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