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Back to Infections Drug Index

Back to Antifungals

Brand Name: Fungulin
Name: Amphotericin B

Pregnancy Category B

Drug classes of Fungulin

Therapeutic actions of Fungulin

As with other polyene antifungals, amphotericin B associates with ergosterol, a membrane chemical of fungi, forming a pore that leads to K+ leakage and fungal cell death. Recently, however, researchers found evidence that pore formation is not necessarily linked to cell death (i.e. Angewandte Chemie Int. Ed. Engl. 2004). The actual mechanism of action may be more complex and multi-faceted.

Indications of Fungulin

Fungulin is an oral preparations of amphotericin B.

  • Main indication is in oral thrush.

Contraindications/cautions of Fungulin

Hypersensitivity to amphotericin or any component of the forumulation.

Avoid other nephrotoxic drugs or adminstration when BUN and serum creatinine, postassium and magnesium levels are elevated. Monitor renal function tests every 2-4 days or daily if at risk of nephrotoxicity.

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Adverse effects of Fungulin

  • Side-effects can be severe; nephrotoxicity (kidney damage) is a major issue. Other side-effects include headache, vomiting, convulsions and fever; it has to be withdrawn occasionally from patients to determine whether their fever is due to amphotericin B or an actual infection. A similar problem exists with cytarabine.


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