Back to Infections Drug Index
Pregnancy Category C
Impairs the synthesis of ergosterol, the main sterol of fungal cell
membranes, allowing increased permeability and leakage of cellular
components and causing cell death.
- Treatment of systemic fungal infections: candidiasis, chronic
mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis,
coccidioidomycosis, histoplasmosis, chromomycosis,
- Treatment of dermatophytosis (recalcitrant infections not responding
topical or griseofulvin therapy)
- Unlabeled uses: treatment of onychomycosis, pityriasis versicolor,
vaginal candidiasis; CNS fungal infections at high doses (800-1,200
mg/d); treatment of advanced prostate cancer at doses of 400 mg q8h
- Topical treatment of tinea corporis and tinea cruris caused by
- Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton
floccosum and the treatment of tinea versicolor caused by Malassezia
furfur (topical administration)
- Reduction of scaling due to dandruff (shampoo)
- Orphan drug use: with cyclosporine to diminish cyclosporine-induced
nephrotoxicity in organ transplant
- Contraindicated in the presence of allergy to ketoconazole; fungal
meningitis; pregnancy; lactation.
- Use caution in the presence of hepatocellular failure (increased risk
Are you a doctor or a nurse?
Do you want to join the Doctors Lounge online medical community?
Participate in editorial activities (publish, peer review, edit) and
give a helping hand to the largest online community of patients.
Click on the link below to see the requirements:
Doctors Lounge Membership
- CNS: Headache, dizziness, somnolence, photophobia
- GI: Hepatotoxicity, nausea, vomiting, abdominal pain
- GU: Impotence, oligospermia (with very high doses)
- Hematologic: Thrombocytopenia, leudopenia, hemolytic anemia
- Hypersensitivity: Urticaria to anaphylaxis
- General: Pruritus, fever, chills, gynecomastia
- Local: Severe irritation, pruritus, stinging with topical application