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Back to Infections Drug Index

Back to Antivirals

Name: Amantadine HCl

Pregnancy Category C

Drug classes

  • Antiviral drug
  • Antiparkinsonism drug

Therapeutic actions

May inhibit penetration of influenza A virus into the host cell; may increase dopamine release in the nigostriatal pathway of parkinsonism patients, relieving their symptoms.


Prevention and treatment of influenza A virus respiratory infection, especially in high-risk patients

Adjunct to late vaccination against influenza A virus, to provide interim coverage; supplement to vaccination in immunodeficient patients; prophylaxis when vaccination is contraindicated
Parkinson's disease and drug-induced extrapyramidal reactions


Allergy to drug product, seizures, liverdisease, eczematoid rash, psychoses, CHF, renal disease, lactation.

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Adverse effects

  • CNS: Lightheadedness, dizziness, insomnia, confusion, irritability, ataxia, psychosis, depression, hallucinations
  • GI: Nausea, anorexia, constipation, dry mouth
  • CV: CHF, orthostatic hypotension, dyspnea
  • GU: Urinary retention

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