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Pregnancy Category C
Synthetic purine nucleoside, which is active against HIV, inhibits cell
protein synthesis, and leads to cell death without viral replication.
Combination therapy with zidovudine in advanced HIV infection
Contraindicated in the presence of life-threatening allergy to any component,
Use caution in the presence of compromised bone marrow, impaired renal
or hepatic function.
- CNS: Headache, insomnia, myalgia, asthenia, malaise, dizziness, paresthesia,
somnolence, peripheral neuropathy
- GI: Nausea, GI pain, diarrhea, anorexia, vomiting, dyspepsia, oral
- Hematologic: Agranulocytopenia, severe anemia requiring transfusions
- Other: Fever, diaphoresis, dyspnea, rash, taste perversion
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