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Pregnancy Category C
Thymidine analogue isolated from the sperm of herring; drug is activated
to a triphosphate form that inhibits replication of some retroviruses, including
HIV, HTLV III, LAV, ARV.
Management of certain adult patients with symptomatic HIV infection (AIDS
and advanced ARC) who have a history of cytologically confirmed P. carinii
pneumonia or an absolute CD4 (T4 helper/inducer) lymphocyte count of less
than 200/mm3 in the peripheral blood before therapy is begun (parenteral)
Management of patients with HIV infection who have evidence of impaired
HIV-infected children older than 3 mo who have HIV-related symptoms or
who are asymptomatic with abnormal laboratory values indicating significant
Contraindicated in the presence of life-threatening allergy to any component,
Use caution in the presence of compromised bone marrow, impaired renal
or hepatic function.
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- CNS: Headache, insomnia, myalgia, asthenia, malaise, dizziness, paresthesia,
- GI: Nausea, GI pain, diarrhea, anorexia, vomiting, dyspepsia
- Hematologic: Agranulocytopenia, severe anemia requiring transfusions
- Other: Fever, diaphoresis, dyspnea, rash, taste perversion