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Forum Name: Viral Infections

Question: Will taking Acyclovir effect my smallpox vaccine?

 billyjun - Fri Feb 12, 2010 8:55 am

Will taking Acyclovir make my smallpox vaccine lesion clear up faster? Is this safe? Will it make the vaccine less effective? I take acyclovir for cold sores but want curious if it will effect my smallpox vaccination in anyway.
 Dr.M.jagesh kamath - Fri Apr 09, 2010 11:07 am

User avatar Hello,Smallpox vaccine is never given now and kept only as a stockpile for genomic research.So you need not worry about this and continue your acyclovir prophylaxis.
However if this relates to chicken pox vaccine the answer is that acyclovir can interact with efficacy of the vaccine, and should not be administered 24hrs after varivax.
Best wishes.


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