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Many ESRD and hemodialysis patients are in a state of oxidative
stress induced by the dialysis process.
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An article published in Hemodialysis International discusses
the role of oxidative stress (OS) in dialysis patients, an
imbalance which can result in long-term health problems.
Potential therapeutic options to restore balance in patients are
also reviewed.
Oxidative stress, an imbalance between toxic compounds and
defense mechanisms, and prevalent in the dialysis process, has
been linked to numerous adverse complications in end-stage renal
disease (ESRD) patients. The imbalance is caused by the
overproduction of reactive oxygen species (ROS), or toxic
compounds, and lack of antioxidants to fight these toxins. In
fact, the hemodialysis process can cause loss of these necessary
antioxidants.
Many ESRD and hemodialysis patients are in a state
of chronic inflammation induced by the dialysis process which
further enhances oxidative stress. This state is strongly
associated with long-term complications such as cardiovascular
disease, malnutrition, poor outcome and low survival.
"It is important to prevent reactive oxygen species
production by improving the biocompatibility of the hemodialysis
system," states Dr. Jean-Paul Cristol, corresponding author.
Antioxidant supplementation and ROS modulation by specific or
non-specific drugs, such as statins, are possible solutions
outlined in the article.
"Correction of OS imbalance appears to be a basic requisite
to prevent complications in long-term dialysis patients" and is
"a promising avenue of research."
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