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Forum Name: Nephrotic Syndrome

Question: Asymptomatic Proteinuria and Altace Treatment Protocol


 Dan Theman - Fri Jan 14, 2005 12:50 pm

I have had proteinuria which went from 1.3g in November 2003 to 5g in October 2004. My Nephrologist has been treating me with 10mg Altace and is adopting a wait and see if it goes down, which if it doesn't, he will want to do a biopsy. I have no symptoms other than the protiein which technically puts me in the nehprotic syndrome stage and my kidney functions are stable. What is a reasonable amount of time to wait and see to determine if the Altace treatment is not working? Also, should I fast for future blood work? I have heard creatinine levels could be unreliable if you eat before the test.
 Dr. Tamer Fouad - Sun Jan 16, 2005 5:48 am

User avatar Hello Dan,
There is no wait and see policy once you are in the nephrotic range. A biopsy should be done right away. I have reviewed the literature and found a rather rare association of nephrotic syndrome with CLL. Luckily if it is a membranous glomerulonephritis then therapy for both conditions (CLL and nephrotic syndrome) could be similar. How well is your leukemia controlled and are you currently taking any therapy for it?
 Dan Theman - Tue Jan 18, 2005 9:31 am

Thanks for the response. I was diagnosed with CLL in 1995 and have not been treated as yet. My WBC counts are normal although my platelets are low (110). Again, do you recommend fasting prior to blood work for kidney functions? Thanks again.
 Dr. Tamer Fouad - Tue Jan 18, 2005 9:59 am

User avatar Avoid eating a diet high in meat or other protein before having a blood urea nitrogen (BUN) test. Serum creatinine on the other hand, is not affected by diet or activity.

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