News  |  Journals  |  Conferences  |  Blogs  |  Articles  |  Forums  |  Twitter   
 

Inherited amyloid neuropathy

Extracellular deposition of the fibrillary protein, amyloid, in peripheral nerve and sensory and autonomic ganglia, as well as around blood vessels in nerves and other tissues.

The disease usually appears in early adulthood.

Manifestations

Affects (1) small neural fibers responsible for pain & temperature leading to loss of the ability to perceive mechanical and thermal injury and tissue damage. As a result, painless injuries present a major hazard of this disorder; in advanced stages they can lead to chronic infections or osteomyelitis of the feet or hands, and may require amputation. (2) autonomic functions manifested as a gastrointestinal motility disorder or orthostatic hypotension. 

The condition is progressive and death usually occurs before 50yrs.

Treatment

none.  

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

 
     
 

 

Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us

Copyright © 2001-2017
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME Articles

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

We subscribe to the HONcode principles of the HON Foundation. Click to verify.We subscribe to the HONcode principles.
Verify here