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Guillain-Barre syndrome

Also known as GBS / Acute postinfectious polyneuropathy.

It is an Inflammatory or immune polyneuropathy. Demylination occurs due to antimyelin ? antiganglioside Antibody. It is the most common immune mediated polyneuropathy. Affects young or middle aged individuals with no sexual predilection.

Other risk factors include mild respiratory or GIT infection or Hodgkin?s disease and surgery.

Clinical suspicion

Acute rapidly progressive predominantly motor neuropathy affecting all voluntary muscles. Pain, autonomic, hypertension and arrhythmias. This condition progresses over hours to days.


CSF shows lymphocytosis up to 20 mm3. proteins > 100mg/dl.

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The first step is urgent hospitalization. DO NOT GIVE STEROIDS. Plasmapheresis and immunoglobulins may help.

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