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Guillain-Barre syndrome
Also known as GBS / Acute postinfectious polyneuropathy.
It is an Inflammatory or immune polyneuropathy. Demylination occurs due
to antimyelin ? antiganglioside Antibody. It is the most common immune mediated
polyneuropathy. Affects young or middle aged individuals with no sexual
predilection.
Other risk factors include mild respiratory or GIT infection or Hodgkin?s
disease and surgery.
Clinical suspicion
Acute rapidly progressive predominantly motor neuropathy affecting all
voluntary muscles. Pain, autonomic, hypertension and arrhythmias. This condition
progresses over hours to days.
Diagnosis
CSF shows lymphocytosis up to 20 mm3. proteins > 100mg/dl.
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Treatment
The first step is urgent hospitalization. DO NOT GIVE STEROIDS. Plasmapheresis
and immunoglobulins may help.
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