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Huntington's disease

It is an autosomal dominant degeneration of the basal ganglia, cerebral cortex especially the frontal lobe. There is decreased levels of GABA, acetyl choline, angiotensin II in the striatum. It is an uncommon condition affecting patients 30-50 years old.

Clinical suspicion

The presence of progressive chorea (basal ganglia) in the presence of behavioral changes and dementia (frontal lobe).

Diagnosis

CT / MRI in fully developed cases shows atrophy especially of basal ganglia.

Treatment

The treatment aims mainly at symptomatic relief of patients. Serpasil 1-2 mg tds and chlorpromazine 100 mg tds may offer some benefit.

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