News  |  Journals  |  Conferences  |  Blogs  |  Articles  |  Forums  |  Twitter   
 

Name: Atropine Sulfate

Pregnancy Category C

Drug classes

  • Anticholinergic
  • Antimuscarinic
  • Parasympatholytic
  • Antiparkinsonism drug
  • Antidote
  • Diagnostic agent (ophthalmic preparations)
  • Belladonna alkaloid

Mechanisms of action

Competitively blocks the effects of acetylcholine at muscarinic cholinergic receptors that mediate the effects of parasympathetic postganglionic impulses, thus depressing salivary and bronchial secretions, dilating the bronchi, inhibiting vagal influences on the heart, relaxing the GI and GU  tracts, inhibiting gastric acid secretion (high doses), relaxing the pupil of the eye (mydriatic effect), and preventing accommodation for near vision (cycloplegic effect); also blocks the effects of  acetylcholine in the CNS.

Indications

  1. Systemic administration: Antisialogogue for preanesthetic medication to prevent or reduce respiratory tract secretions
  2. Treatment of parkinsonism; relieves tremor and rigidity
  3. Restoration of cardiac rate and arterial pressure during anesthesia when vagal stimulation produced by intra-abdominal traction causes a decrease in pulse rate, lessening the degree of AV block when increased vagal tone is a factor (eg, some cases due to digitalis)
  4. Relief of bradycardia and syncope due to hyperactive carotid sinus reflex
  5. Relief of pylorospasm, hypertonicity of the small intestine, and hypermotility of the colon
  6. Relaxation of the spasm of biliary and ureteral colic and bronchospasm
  7. Relaxation of the tone of the detrusor muscle of the urinary bladder in the treatment of urinary tract disorders
  8. Control of crying and laughing episodes in patients with brain lesions
  9. Treatment of closed head injuries that cause acetylcholine release into CSF, EEG abnormalities, stupor, neurologic signs
  10. Relaxation of uterine hypertonicity
  11. Management of peptic ulcer
  12. Control of rhinorrhea of acute rhinitis or hay fever
  13. Antidote (with external cardiac massage) for cardiovascular collapse from overdose of parasympathomimetic (cholinergic) drugs (choline esters, pilocarpine), or cholinesterase inhibitors (eg, physostigmine, isoflurophate, organophosphorus insecticides)
  14. Antidote for poisoning by certain species of mushroom (eg, Amanita muscaria)
  15. Ophthalmic preparations: diagnostically to produce mydriasis and cycloplegiapupillary dilation in acute inflammatory conditions of the iris and uveal tract

Contraindications/cautions

  • Contraindicated in the presence of hypersensitivity to anticholinergic drugs.
  • Systemic administration: Contraindicated in the presence of glaucoma, adhesions between iris and lens, stenosing peptic ulcer, pyloroduodenal obstruction, paralytic ileus, intestinal atony, severe ulcerative colitis, toxic megacolon, symptomatic prostatic hypertrophy, bladder neck
    obstruction, bronchial asthma, COPD, cardiac arrhythmias, tachycardia, myocardial ischemia, impaired metabolic, liver or kidney function, myasthenia gravis.
  • Use caution in the presence of Down syndrome, brain damage, spasticity, hypertension, hyperthyroidism, lactation.
  • Ophthalmic solution: Contraindicated with glaucoma or tendency to glaucoma.
advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

 
     
 

 

Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us

Copyright © 2001-2017
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME Articles

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

We subscribe to the HONcode principles of the HON Foundation. Click to verify.We subscribe to the HONcode principles.
Verify here