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Name: Dicyclomine hydrochloride

Pregnancy Category C

Drug classes

  • Antispasmodic
  • Anticholinergic
  • Antimuscarinic
  • Parasympatholytic

Mechanisms of action

Direct GI smooth muscle relaxant; competitively blocks the effects of acetylcholine at muscarinic cholinergic receptors that mediate the effects of parasympathetic postganglionic impulses, thus relaxing the GI tract.

Indications

Treatment of functional bowel or irritable bowel syndrome (irritable colon, spastic colon, mucous colitis)

Contraindications/cautions

Contraindicated in the presence of glaucoma; adhesions between iris and lens, stenosing peptic ulcer, pyloroduodenal obstruction, paralytic ileus, intestinal atony, severe ulcerative colitis, toxic megacolon, symptomatic prostatic hypertrophy, bladder neck obstruction, bronchial asthma, COPD, cardiac arrhythmias, tachycardia, myocardial ischemia; impaired metabolic, liver, or kidney function, myasthenia gravis; lactation.

Use caution in the presence of Down's syndrome, brain damage, spasticity, hypertension, hyperthyroidism.

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