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 Headlines:

 
 

 

Back to Drug index

Back to Anticholinergics

Name: Dicyclomine hydrochloride

 

The FDA approved Xolair?, the first in a new class of asthma therapies that are bioengineered to target IgE.

 
 

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Asthma disease review

 
   
 
     

Pregnancy Category C

Drug classes

  • Antispasmodic
  • Anticholinergic
  • Antimuscarinic
  • Parasympatholytic

Mechanisms of action

Direct GI smooth muscle relaxant; competitively blocks the effects of acetylcholine at muscarinic cholinergic receptors that mediate the effects of parasympathetic postganglionic impulses, thus relaxing the GI tract.

Indications

Treatment of functional bowel or irritable bowel syndrome (irritable colon, spastic colon, mucous colitis)

Contraindications/cautions

Contraindicated in the presence of glaucoma; adhesions between iris and lens, stenosing peptic ulcer, pyloroduodenal obstruction, paralytic ileus, intestinal atony, severe ulcerative colitis, toxic megacolon, symptomatic prostatic hypertrophy, bladder neck obstruction, bronchial asthma, COPD, cardiac arrhythmias, tachycardia, myocardial ischemia; impaired metabolic, liver, or kidney function, myasthenia gravis; lactation.

Use caution in the presence of Down's syndrome, brain damage, spasticity, hypertension, hyperthyroidism.

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Adverse effects

  • CNS: Blurred vision, mydriasis, cycloplegia, photophobia, increased intraocular pressure
  • GI: Dry mouth, altered taste perception, nausea, vomiting, dysphagia, heartburn, constipation, bloated feeling, paralytic ileus, gastroesophageal reflux
  • CV: Palpitations, tachycardia
  • GU: Urinary hesitancy and retention; impotence
  • Local: Irritation at site of IM injection
  • Other: Decreased sweating and predisposition to heat prostration, suppression of lactation
 

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