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Name: Cyclobenzaprine hydrochloride

Pregnancy Category B

Drug classes

Centrally acting skeletal muscle relaxant

Therapeutic actions

Precise mechanism of action not known; does not directly relax tense skeletal muscles but appears to act mainly at brain stem levels or in the spinal cord.


Relief of discomfort associated with acute, painful musculoskeletal conditions, as an adjunct to rest, physical therapy

Unlabeled use: adjunct in the management of fibrositis syndrome


Contraindicated in the presence of hypersensistivity to cyclobenzaprine, acute recovery phase of myocardial infarction, arrhythmias, heart block or conduction disturbances, CHF, hyperthyroidism.

Use with caution in the presence of urinary retention, angle-closure glaucoma, increased intraocular pressure, lactation.

Adverse effects

  • CNS: Drowsiness, dizziness, fatigue, tiredness, asthenia, blurred vision, headache, nervousness, confusion
  • GI: Dry mouth, nausea, constipation, dyspepsia, unpleasant taste, liver toxicity in preclinical studies
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