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GIST patients show good response rates to new drug
June 5-8, 2004. New Orleans, LA.
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The ASCO (American Society Of Clinical Oncology) Annual Meeting is the
premier oncology educational and scientific event.
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Those with gastrointestinal stromal tumors (GIST) resistant to imatinib
(Gleevec) may benefit from a new drug according to the results from a
phase II study.
More than half of patients develop resistance to Imatinab, which is
currently the first-line therapy.
The experimental drug, code named SU11248, showed response rates in 60
of the 92 patients treated who were resistant to imatinab.
SU11248 blocks multiple pathways involving tyrosine kinase, VEGF, PDGF,
and the KIT receptor. Patients with mutations in KIT exon 9 showed the
strongest response.
SU11248 had a safety profile similar to that of imatinib, such as
fatigue, nausea, diarrhea, gastrointestinal bleeding, and an increase in
blood pressure in some patients, probably due to the drug's angiogenic
effects.
ASCO 2004 Annual Meeting: Abstract 3001. Presented June 6, 2004.
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Lounge or
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Copyright © 2004 The Doctors Lounge.
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