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Chronic myeloid leukemia
Introduction

Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disorder resulting from the neoplastic transformation of the primitive hemopoietic stem cell. The disease is monoclonal in origin, affecting myeloid, monocytic, erythroid, megakaryocytic, B-cell, and, sometimes, T-cell lineages.

Incidence

CML accounts for 15% of all leukemias in adults. In adults the incidence is approximately 1 to 1.5 cases per 100,000 population.

Estimated new cases and deaths from chronic myeloid leukemia in the United States in 2005:

  • New cases: 4,600
  • Deaths: 850

Gender

The male-to-female ratio is 1.4 to 2.2:1.

Age

The median age of patients with Ph1-positive CML (Chronic Myeloid Leukemia) is 67 years of age.

Race and ethnicity

Incidence rates are similar among all race/ethnicities.

Geography

CML has been observed in studies following the atom bomb explosions in Japan in 1945.

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