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Chronic myeloid leukemia
Causes and risk factors
In the great majority of patients, a causative factor cannot be
identified. Some associations with genetic and environmental factors
have been reported, but in most cases, no such factors can be
identified.
Radiation exposure
Nuclear and radiation exposures, including therapeutic radiation,
have been associated with the development of CML. CML has been
observed in studies following the atom bomb explosions in Japan in
1945, and by earlier studies in radiologists and in patients with
ankylosing spondylitis treated with radiation therapy. However, this
accounts for only a small portion of cases.
Benzene exposure
Exposure to chemicals has not been associated with greater risk
except for the use of benzene.
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Genetic factors
There is little evidence linking genetic factors to CML.
Offspring of parents with CML do not have a higher incidence of CML
than the general population.
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