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Back to Oncology Diseases
Hodgkin's lymphoma
Causes and risk factors
There are no well-defined risk factors for development of
Hodgkin's lymphoma and its causes remain unknown. Certain
associations have been noted that provide clues to possible
etiologic factors. Familial aggregation may imply genetic factors,
but other epidemiologic findings suggest an abnormal response to an
infective agent. Both factors may play a role in the pathogenesis of
the disease.
Familial factors
- Same-sex siblings of patients with Hodgkin?s disease have a
10 times higher risk for the disease.
Patient-child combinations are more common than spouse pairings.
- The monozygotic twin sibling of a patient with Hodgkin?s
disease has a 99 times higher risk of developing Hodgkin?s
disease than a dizygotic twin sibling of a patient with
Hodgkin?s disease.
- Higher risk for Hodgkin?s disease is associated with few
siblings, single-family houses, early birth order, and fewer
playmates all of which decrease exposure to infectious agents at
an early age.
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