Powered by


                    Home  |  Forums  |  Humor  |  Advertising  |  Contact
   Health Questions

   News via RSS






   Forum Archives





















   Primary Care






   Other Sections


   Research Tools

   Medical Tutorials

   Medical Software




Hepatocellular carcinoma
Causes and risk factors

Updated: October 29, 2005

Hepatitis B virus

High titres of HBsAg and HBcAb are frequently found in patients with hepatocellular carcinoma. The close geographic relationship between hepatitis B incidence and hepatocellular carcinoma rates is well recognized. In endemic areas of HCC is increased 140 fold in HBsAg carriers. Anti-HBcAb was found in the serum of up to 90% of cases in the Far East.


Hepatocellular carcinoma is associated with cirrhosis in 50% to 80% of patients, alcoholism being the most common cause of hepatic cirrhosis. While 5% of cirrhotic patients eventually develop hepatocellular cancer, which is often multifocal.


Aflatoxin has also been implicated as a factor in the etiology of primary liver cancer in parts of the world where this mycotoxin occurs in high levels in ingested food.

advertisement.gif (61x7 -- 0 bytes)

Are you a doctor or a nurse?

Do you want to join the Doctors Lounge online medical community?

Participate in editorial activities (publish, peer review, edit) and give a helping hand to the largest online community of patients.

Click on the link below to see the requirements:

Doctors Lounge Membership Application

Other factors

  • Oral contraceptive use for 8 or more years is associated with increased risk of HCC.
  • Cigarette smoking, alcohol intake, diabetes and insulin intake appear to be significant risk factors.
  • Mutations of p53 tumor suppressor gene have been reported in 50% of the cases.
  • Workers who were exposed to vinyl chloride before controls on vinyl chloride dust were instituted developed sarcomas in the liver, most commonly angiosarcomas.
previous.gif (72x17 -- 347 bytes) next.gif (72x17 -- 277 bytes)



 advertisement.gif (61x7 -- 0 bytes)



Copyright 2001-2017
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Links | Humor
Forum Archive
CME Articles

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email