Advertisement
 

doctorslounge.com

 
Powered by
Careerbuilder

 

                    Home  |  Forums  |  Humor  |  Advertising  |  Contact
   Ask a Doctor

   News via RSS

   Newsletter

   Oncology

   News

 

 Conferences


   CME

   Forum Archives

   Diseases

   Symptoms

   Labs

   Procedures

   Drugs

   Links
   Specialties

   Cardiology

   Dermatology

   Endocrinology

   Fertility

   Gastroenterology

   Gynecology

   Hematology

   Infections

   Nephrology

   Neurology

   Oncology

   Orthopedics

   Pediatrics

   Pharmacy

   Primary Care

   Psychiatry

   Pulmonology

   Rheumatology

   Surgery

   Urology

   Other Sections

   Membership

   Research Tools

   Medical Tutorials

   Medical Software

 

 Headlines:

 
 

Non-Hodgkin's Lymphoma
Symptoms and signs

1. Indolent lymphomas

As a group, low-grade lymphomas are characterized by indolent clinical behavior and comparatively prolonged survival (median survival, 6-10 years). Most patients have advanced- stage disease at diagnosis, and only about 10%-20% have stage I or II disease.

Follicular lymphoma

  • They usually appear above the age of 50 and present with generalized lymphadenopathy.
  • They commonly involve the bone marrow and spleen.
  • Despite the relative incurability of the disease in its advanced stages, follicular lymphoma patients tend to experience a long overall survival (8-12 years).

Lymphoplasmacytic Lymphoma

  • Lymphoplasmacytic Lymphoma is an indolent lymphoma associated with a monoclonal paraprotein of immunoglobulin M type.
  • They usually present with generalized lymph node, splenic and bone marrow involvement.
  • Some patients may develop hyperviscosity syndrome (which may lead to retinopathy, congestive heart failure and CNS dysfunction) due to excessive paraprotein secretion.
  • Patients may also experience chronic cold agglutinin disease.

Marginal zone lymphomas

  • Nodal marginal zone lymphomas involve the nodes and are called monocytoid B-cell lymphomas
  • Extranodal marginal zone lymphoma involves the extranodal sites (gastrointestinal tract, thyroid, lung, breast, skin), they are called mucosa-associated lymphatic tissue (MALT) lymphomas.

Splenic marginal zone lymphoma

  • Splenic marginal zone lymphoma is an indolent lymphoma that is marked by massive splenomegaly and peripheral blood and bone marrow involvement, usually without adenopathy.
  • Splenectomy may result in prolonged remission, otherwise it is treated as low grade lymphoma.
advertisement.gif (61x7 -- 0 bytes)
 

Are you a doctor or a nurse?

Do you want to join the Doctors Lounge online medical community?

Participate in editorial activities (publish, peer review, edit) and give a helping hand to the largest online community of patients.

Click on the link below to see the requirements:

Doctors Lounge Membership Application


2. Intermediate to high grade lymphoma

The clinical manifestations of intermediate- and high-grade NHLs are diverse and depend on the site of disease involvement. These tumors have a rapid growth rate and present as painless masses that cause symptoms when they infiltrate tissues or obstruct organs.

  • Lymphomas more frequently affects the lymph nodes, spleen, liver, and bone marrow, but any extranodal site may also be primarily involved.

  • As with Hodgkin's disease, NHL also presents with systemic B symptoms, including fever, which may or may not have the Pel-Ebstein relapsing pattern; drenching night sweats; and more than 10% weight loss. Generalized pruritus may also be present.
  • Nonparathyroid hormone induced hypercalcemia occurs in approximately 10% of patients.
previous.gif (72x17 -- 347 bytes) next.gif (72x17 -- 277 bytes)

 

 

 advertisement.gif (61x7 -- 0 bytes)

 

 



We subscribe to the HONcode principles of the HON Foundation. Click to verify.
We subscribe to the HONcode principles. Verify here

Privacy Statement | Terms & Conditions | Editorial Board | About us
Copyright 2001-2012 DoctorsLounge. All rights reserved.