Powered by


                    Home  |  Forums  |  Humor  |  Advertising  |  Contact
   Health Questions

   News via RSS






   Forum Archives





















   Primary Care






   Other Sections


   Research Tools

   Medical Tutorials

   Medical Software




Back to Oncology Drug index

Back to Alkylating Agents


Melphalan, L-PAM, L-Sarcolysin, Phenylalanine mustard

Pregnancy Category D

Drug classes

Alkylating Agent

Mechanism of action

A derivative of mechlorethamine that inhibits DNA and RNA synthesis via formation of carbonium ions; cross-links strands of DNA.


Palliative treatment of:

  • Multiple Myeloma
  • Ovarian adenocarcinoma
  • Rhabdomyosarcoma
  • Neuroblastoma
  • Breast cancer


  • Hypersensitivity to the drug
  • Myelosuppression
  • Pregnancy
advertisement.gif (61x7 -- 0 bytes)

Are you a doctor or a nurse?

Do you want to join the Doctors Lounge online medical community?

Participate in editorial activities (publish, peer review, edit) and give a helping hand to the largest online community of patients.

Click on the link below to see the requirements:

Doctors Lounge Membership Application

Adverse effects

  • Hematology:  Myelosuppression especially leukocytic count and platelets, hemolytic anemia
  • GIT: emetogenic potential: <100mg/m2 low, >100mg/m2 high, mucositis (rare), diarrhea (rare)
  • Skin: Alopecia, pruritis, rash, vesicular eruptions
  • Respiratory: interstitial fibrosis, pneumonitis
  • CVS: Vasculitis
  • Endocrine: Amenorrhea, sterility, SIADH
  • Other: 2ry leukemia, hypersensitivity, hemorrhagic cystits, transaminases increase, hepatitis

 advertisement.gif (61x7 -- 0 bytes)



Copyright 2001-2017
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Links | Humor
Forum Archive
CME Articles

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email