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Cisplatin

CDDP, Platinol, Platinol-AQ

Pregnancy Category D

Drug classes

Alkylating Agents
Antineoplastics

Mechanism of action

Cytotoxic: heavy metal that inhibits cell replication; cell cycle nonspecific.

Indications

1. Metastatic testicular tumors: combination therapy with bleomycin sulfate and vinblastine sulfate after surgery or radiotherapy
2. Metastatic ovarian tumors: as single therapy in resistant patients or in
   combination therapy with doxorubicin after surgery or radiotherapy
3. Advanced bladder cancer: single agent for transitional cell bladder cancer no longer amenable to surgery or radiotherapy

Contraindications

1. Allergy to cisplatin
2. Platinum-containing products
3. Hematopoietic depression
4. Impaired renal function
5. Hearing impairment
6. Pregnancy
7. Lactation

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Adverse effects

• CNS: Ototoxicity, peripheral neuropathies, seizures, loss of taste
• GI: Nausea, vomiting, anorexia
• Hematologic: Leukopenia, thrombocytopenia, anemia, hypomagnesemia, hypocalcemia, hypokalemia, hypophosphatemia, hyperuricemia
• GU: Nephrotoxicity, dose limiting
• Hypersensitivity: Anaphylactic-like reactions, facial edema, bronchoconstriction, tachycardia, hypotension (treat with epinephrine, corticosteroids, antihistamines)

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