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Cisplatin

CDDP, Platinol, Platinol-AQ

Pregnancy Category D

Drug classes

Alkylating Agents
Antineoplastics

Mechanism of action

Cytotoxic: heavy metal that inhibits cell replication; cell cycle nonspecific.

Indications

  1. Metastatic testicular tumors: combination therapy with bleomycin sulfate and vinblastine sulfate after surgery or radiotherapy
  2. Metastatic ovarian tumors: as single therapy in resistant patients or in
    combination therapy with doxorubicin after surgery or radiotherapy
  3. Advanced bladder cancer: single agent for transitional cell bladder cancer no longer amenable to surgery or radiotherapy

Contraindications

  1. Allergy to cisplatin
  2. Platinum-containing products
  3. Hematopoietic depression
  4. Impaired renal function
  5. Hearing impairment
  6. Pregnancy
  7. Lactation

Adverse effects

  • CNS: Ototoxicity, peripheral neuropathies, seizures, loss of taste
  • GI: Nausea, vomiting, anorexia
  • Hematologic: Leukopenia, thrombocytopenia, anemia, hypomagnesemia, hypocalcemia, hypokalemia, hypophosphatemia, hyperuricemia
  • GU: Nephrotoxicity, dose limiting
  • Hypersensitivity: Anaphylactic-like reactions, facial edema, bronchoconstriction, tachycardia, hypotension (treat with epinephrine, corticosteroids, antihistamines)

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