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Back to Oncology Drug index
Bleomycin sulfate
BLM, Blenoxane, Bleo
Pregnancy Category D
Drug classes
Antibiotics
Antineoplastics
Mechanism of action
Inhibits DNA, RNA, and protein synthesis in susceptible cells,
preventing cell division; cell cycle phase-specific agent with major
effects in G2 and M phases.
Indications
- Palliative treatment of squamous cell
carcinoma, lymphomas, testicular carcinoma, alone
or in combination with other drugs
Contraindications
- Allergy to bleomycin sulfate
- Lactation
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Adverse effects
- GI: Hepatic toxicity,
stomatitis, vomiting, anorexia, weight loss
- Respiratory: Dyspnea, rales,
pneumonitis, pulmonary fibrosis
- GU: Renal toxicity
- Dermatologic: Rash, striae,
vesiculation, hyperpigmentation, skin tenderness, hyperkeratosis,
nail changes, alopecia, pruritis
- Hypersensitivity:
Idiosyncratic reaction similar to anaphylaxis: hypotension, mental
confusion, fever, chills, wheezing (especially in lymphoma patients,
1% occurrence)
- Other: Fever, chills
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