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Back to Oncology Drug index

Back to Mitotic inhibitors

Name: Vinblastine Sulfate

Pregnancy Category D

Drug classes

  • Mitotic inhibitor
  • Antineoplastic agent

Therapeutic actions

Affects cell energy production required for mitosis and interferes with nucleic acid synthesis; has antimitotic effect and causes abnormal mitotic figures.


Palliative treatment for generalized Hodgkin's disease (stages III and IV), lymphocytic lymphoma, histiocytic lymphoma, mycosis fungoides, advance testicular carcinoma, Kaposi's sarcoma, Letterer-Siwe disease

Palliative treatment of choriocarcinoma, breast cancer unresponsive to other therapies

Hodgkin's disease (advanced) alone or in combination therapies

Advanced testicular germinal-cell cancers alone or in combination therapy


Contraindicated in the presence of allergy to vinblastine, leukopenia, acute infection, pregnancy, lactation.

Use caution in the presence of liver disease.

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Adverse effects

  • CNS: Numbness, paresthesias, peripheral neuritis, mental depression, loss of deep tendon reflexes, headache, seizures, malaise, weakness, dizziness
  • GI: Nausea, vomiting, pharyngitis, vesiculation of the mouth, ileus, diarrhea, constipation, anorexia, abdominal pain, rectal bleeding, hemorrhagic enterocolitis
  • Hematologic: Leukopenia
  • GU: Aspermia
  • Dermatologic: Topical epilation (loss of hair), vesiculation of the skin
  • Local: Local cellulitis, phlebitis, sloughing of the skin if extravasation occurs
  • Other: Pain in tumor site Pregnancy Category D

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