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Back to Oncology Drug index

Back to Mitotic inhibitors

Name: Vinblastine Sulfate

Pregnancy Category D

Drug classes

  • Mitotic inhibitor
  • Antineoplastic agent

Therapeutic actions

Affects cell energy production required for mitosis and interferes with nucleic acid synthesis; has antimitotic effect and causes abnormal mitotic figures.

Indications

Palliative treatment for generalized Hodgkin's disease (stages III and IV), lymphocytic lymphoma, histiocytic lymphoma, mycosis fungoides, advance testicular carcinoma, Kaposi's sarcoma, Letterer-Siwe disease

Palliative treatment of choriocarcinoma, breast cancer unresponsive to other therapies

Hodgkin's disease (advanced) alone or in combination therapies

Advanced testicular germinal-cell cancers alone or in combination therapy

Contraindications/cautions

Contraindicated in the presence of allergy to vinblastine, leukopenia, acute infection, pregnancy, lactation.

Use caution in the presence of liver disease.

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Adverse effects

  • CNS: Numbness, paresthesias, peripheral neuritis, mental depression, loss of deep tendon reflexes, headache, seizures, malaise, weakness, dizziness
  • GI: Nausea, vomiting, pharyngitis, vesiculation of the mouth, ileus, diarrhea, constipation, anorexia, abdominal pain, rectal bleeding, hemorrhagic enterocolitis
  • Hematologic: Leukopenia
  • GU: Aspermia
  • Dermatologic: Topical epilation (loss of hair), vesiculation of the skin
  • Local: Local cellulitis, phlebitis, sloughing of the skin if extravasation occurs
  • Other: Pain in tumor site Pregnancy Category D
 

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