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Forum Name: Multiple Myeloma

Question: Myeloma in the brain......


 payton49 - Tue Feb 10, 2009 4:07 am

My freind has just been told that the Myeloma has gone to her brain. The doctor is going to give her chemo via a lumber puncture. Can anyone give me any information on Myeloma in the brain and what we can expect. Thank you
 Dr. Tamer Fouad - Fri Mar 20, 2009 1:47 pm

User avatar Hello,

I hope your friend is doing well. Central Nervous System (CNS) involvement with multiple myeloma is extremely rare. It is diagnosed by finding malignant plasma cells in the spinal fluid by lumbar puncture. This is usually ordered after a patient with myeloma presents with CNS symptoms that are suspicious.

Usually these patients have advanced disease and various chromosomal abnormalities such as del 13q and p53 mutations. These abnormalities confer poor prognosis.

Unfortunately, there are two few cases to draw general conclusions about what may happen to your friend but most of these cases have been treated with CNS directed therapy (eg, intrathecal chemotherapy) as well as bone marrow transplants.

Sadly, most of the cases reported in the literature do not do well altogether. However, like I said there are too few of those and any generalization would be stated with caution.

Good luck!

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