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Forum Name: Breast Cancer
Question: Area under the curve
|hpa - Wed Feb 11, 2004 9:36 am|
Could anyone tell me an online source for an explanation of area under the curve?
|Dr. Tamer Fouad - Wed Feb 11, 2004 10:17 am|
Click here for a previous discussion of the topic:
Area under the curve
|hpa - Sun Feb 15, 2004 3:21 am|
I have seen the previous post. Unfortunately it uses the term it seeks to explain in the explanation. It merely says: "Thus, the area under the curve (AUC) has been developed to better calculate the dose of carboplatin than could be calculated if just BSA were used."
I couldn't find a clear definiton in the online med. dictionaries or elsewhere.
|Dr. Tamer Fouad - Sun Feb 15, 2004 4:10 am|
Chemotherapy is known to be very toxic. In determining the dose of a particular drug the side effects of the drug are the limiting factor. In most drugs the relationship between the dose of the drug and the side effects is linear. In the case of carboplatin the effect is also dose dependent, but as shown by Egorin and Calvert, the effect is most closely related to the drug exposure in an individual as measured by the area under the curve that plots the carboplatin plasma concentration against time (Area under the curve).
Both groups derived formulas to predict toxicity. In the Calvert formula it takes into account effects of renal toxicity. The glomerular filtration rate is measured directly with labeled EDTA. Chatelut's formula uses creatinine clearance (easier to calculate) which is not as accurate as the Calvert formula but still superior to conventional dosing.
The forumula has been widely individualized. Patients who are elderly or have a poor performance status have a higer risk of toxicity hence some formulas take into account age as well.
To examine the actual formula for the area under the curve see this page.
The recommended dosage of carboplatin in previously untreated patients with a normal renal function is 400 mg/m². Usually the carboplatin dosage is calculated using the target area under the free carboplatin plasma concentration versus time curve (AUC) and the pre-treatment glomerular filtration rate (GFR):
dose (mg) = target AUC x (GFR + 25)
A target AUC of 5 approximates 400 mg/m²
|hpa - Tue Feb 17, 2004 12:02 pm|
Thank you very much for your detailed reply.
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