Advertisement

 

doctorslounge.com

 
Powered by
Careerbuilder

 

                    Home  |  Forums  |  Humor  |  Advertising  |  Contact
   Ask a Doctor

   News via RSS

   Newsletter

   Home

   News

   Conferences

   CME

   Forum Archives

   Diseases

   Symptoms

   Labs

   Procedures

   Drugs

   Links

advertisement.gif (61x7 -- 0 bytes)

   Specialties

   Cardiology

   Dermatology

   Endocrinology

   Fertility

   Gastroenterology

   Gynecology

   Hematology

   Infections

   Nephrology

   Neurology

   Oncology

   Orthopedics

   Pediatrics

   Pharmacy

   Primary Care

   Psychiatry

   Pulmonology

   Rheumatology

   Surgery

   Urology

   Other Sections

   Membership

   Research Tools

   Medical Tutorials

   Medical Software

     
 
 

 Headlines:

 
 
 
Last Updated: Jun 12, 2009 - 3:53:09 PM

Risk of breast cancer mutations underestimated for Asian women
   
American Society of Clinical Oncology
Sep 12, 2008 - 1:39:15 PM
Email this article
 Printer friendly page
Researchers from the U.S. and Canada found that two computer models widely used to determine who should undergo genetic testing for BRCA mutations under predicted mutation frequency in Asian-American women by 50 percent. Mutations in the BRCA1 and BRCA2 genes significantly increase the risk of breast and ovarian cancers, and women who learn they have these mutations are encouraged to seek more frequent cancer screening or may undertake other measures to reduce their cancer risk, such as preventive mastectomy or removal of the ovaries.

The incidence of breast cancer among Asians is generally lower than among Caucasians. However, breast cancer rates are increasing in China, Korea and other Asian countries and among Asian immigrants to the United States, which has led to increasing demand for BRCA1/2 mutation testing in this population.

“Our findings indicate that Asian-American women with BRCA mutations may not be referred for genetic testing as often as they should be,” said lead author Allison Kurian, MD, MSc, assistant professor of medicine and of health research and policy at Stanford University School of Medicine. “While women of Asian descent have, in the past, been at lower risk for breast and ovarian cancers compared with other races, these findings will be important for physicians to keep in mind when assessing whether their Asian-American patients are candidates for BRCA mutation testing.”

The models, called BRCAPRO and Myriad II, are commonly used to determine which patients inquiring about genetic consultation would benefit most from genetic testing for BRCA mutations. These models were initially created using data on BRCA mutations in Caucasians, and some studies have shown these models accurately predicted gene mutation risk in other minority groups, including African-Americans and Hispanics.

For this study, researchers compared the results of the BRCAPRO and Myriad II computer prediction models with the findings of genetic testing in 200 Asian-Americans and 200 matched non-Jewish Caucasians. (Jewish women were excluded from the analysis because of their higher prevalence of BRCA mutations.) The models accurately predicted the number of Caucasian BRCA1/2 mutation carriers (25 observed versus 24 predicted by BRCAPRO and 25 by Myriad II). However, the models significantly under predicted Asian mutation carriers (49 observed versus 25 predicted by BRCAPRO and 26 by Myriad II). For BRCAPRO, the difference was especially pronounced for Asian BRCA2 mutation carriers (26 observed versus only 4 predicted); the Myriad II prediction model does not have the ability to differentiate between BRCA1 and BRCA2 mutation risk.

 
Top of Page

Email this article
Printer friendly page

advertisement.gif (61x7 -- 0 bytes)
 

Are you a doctor or a nurse?

Do you want to join the Doctors Lounge online medical community?

Participate in editorial activities (publish, peer review, edit) and give a helping hand to the largest online community of patients.

Click on the link below to see the requirements:

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 



We subscribe to the HONcode principles of the HON Foundation. Click to verify.
We subscribe to the HONcode principles. Verify here

Privacy Statement | Terms & Conditions | Editorial Board | About us
Copyright © 2001-2007 The Doctors Lounge. All rights reserved.