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Cancer
Chemotherapy Regimen for Bladder Cancer
CAP-M
bladder(4)
_________________________________________________________________
cytoxan......... 500 mg/sqm IV days 1 and 21.
adriamycin...... 40 mg/sqm IV days 1 and 21.
cisplatin....... 40 mg/sqm IV days 2 and 22.
methotrexate.... 40 mg/sqm IV days 42, 49, 56, 63, 70, 77 and
84.
FREQUENCY....... Repeat cycle every 15 weeks (105 days).
reference...
Citrin DL. Hogan TF. Davis TE. A study of cyclophosphamide,
adriamycin, cis-platinum, and methotrexate in advanced transitional
cell carcinoma of the urinary tract. Cancer. 51(1):1-4, 1983
Jan 1.
abstract...
Twenty patients with locally advanced and/or metastatic transitional
cell cancer of the urinary tract were treated with cyclophosphamide
500 mg/m2, Adriamycin (doxorubicin) 40 mg/m2 and cis-platinum (CDDP)
40 mg/m2 given every three weeks for 2 cycles, alternating with
methotrexate 40 mg/m2 weekly for six weeks (CAP-M). Five of thirteen
(38%) evaluable patients responded, with a significant
prolongation of survival. Toxicity in 18 evaluable patients was
mild to moderate. Methotrexate can be combined with CAP with significant
reduction in dosage of cyclophosphamide, Adriamycin and CDDP and
reduced toxicity, without major loss of efficacy. The precise role
of methotrexate in combination chemotherapy of bladder cancer remains
to be defined.
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