CISCA                                                bladder(5,6)
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  cisplatin....... 100 mg/sqm IV day 2.
  cytoxan......... 650 mg/sqm IV day 1.
  adriamycin...... 50 mg/sqm IV day 1.
  FREQUENCY....... Repeat cycles every 21 to 28 days.


    5. Samuels ML, et.al. Cytoxan, adriamycin and cisplatin (CISCA) 
       in metastatic bladder cancer. Proc Am Assoc Cancer Res 
       21:137, 1980.

  reference...
    Sternberg JJ.  Bracken RB.  Handel PB.  Johnson DE. 
    Combination chemotherapy (CISCA) for advanced urinary tract 
    carcinoma. A preliminary report. JAMA.  238(21):2282-7, 1977 
    Nov 21. 
  abstract...
    Twelve patients with metastatic transitional cell carcinoma 
    from the urinary bladder were treated with a combination 
    chemotherapy program consisting of cisplatinum, 
    cyclophosphamide, and doxorubicin hydrochloride (CISCA). Ten 
    patients had conditions for which a response to therapy could 
    be determined, and nine achieved an objective response (one 
    complete response, eight partial responses). Two additional 
    patients with metastatic transitional cell carcinoma from the 
    renal pelvis were also treated, and one achieved a partial 
    response. In our experience, CISCA combination chemotherapy 
    has given the highest response rate of any protocol thus far 
    tested in advanced, metastatic urinary tract carcinoma.