VML                                             osteosarcoma(109)
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  vincristine..... 2.0 mg/sqm (maximum sungle dose 2.0 mg) IV on 
                   day 1.
  methotrexate.... 3,000 to 7,500 mg/sqm IV over 6 h beginning 30 
                   minutes after vincristine.
  leucovorin...... 15 mg IV every 3 h times 8, then 15 mg orally 
                   every 6 h times 8, beginning 3 h after 
                   methotrexate infusion is completed.
  FREQUENCY....... Repeat cycle every 21 days.

  reference...
    Jaffe N.  Frei E 3d.  Watts H.  Traggis D. High-dose 
    methotrexate in osteogenic sarcoma: a 5-year experience. 
    Cancer Treatment Reports.  62(2):259-64, 1978 Feb. 
  abstract...