|
|
|
|
|
| |
|
Headlines:
|
 |
Back to index
Cancer
Chemotherapy Regimen for Brain Cancer
BCNU-FU brain(12)
_________________________________________________________________
carmustine...... 180 mg/sqm IV day 1.
fluorouracil.... 1,000 mg/sqm/day IV infusion for 72 hours
beginning on day 15.
FREQUENCY....... Repeat cycle every 6 weeks until there is
evidence of tumor progression.
reference...
Levin VA. Hoffman WF. Pischer TL. Seager ML. Boldrey EB.
Wilson CB. BCNU-5-fluorouracil combination therapy for
recurrent malignant brain tumors. Cancer Treatment Reports.
62(12):2071-6, 1978 Dec.
abstract...
Twenty-nine patients with recurrent malignant brain tumors were evaluated. BCNU (180 mg/m2) was administered iv on Day 1and 5-fluorouracil (1 g/m2/day) was given by continuous
infusion on Days 15--17. Courses were repeated every 6 weeks until tumor progression occurred. Before each course, a neurologic examination and radionuclide and computerized
tomographic scans were performed. Response and progression were defined as
improvement or deterioration, respectively, in at least two of the three tests. Nine of 29 patients (31%) responded to therapy, five of 29 (17%) showed progression, and
15 of 29 (52%) had disease stability. The estimated median time to progression was 27 weeks for all patients, 34 weeks for the response group, and 25 weeks for the stable group. Of all 29 patients, 24 (83%) had tumor progression arrested; 40% with response and 6% with stable disease were continuing therapy after 1 year. The stable disease group was larger and
the duration of stability was longer than that seen in previous studies. Evaluated by time to progression, a BCNU-5-fluorouracil combination is superior to either BCNU alone or a BCNU-procarbazine combination. |
|
|
|
|
Are you a doctor or a nurse?
Do you want to join the Doctors Lounge online medical community?
Participate in editorial activities (publish, peer review, edit) and
give a helping hand to the largest online community of patients.
Click on the link below to see the requirements:
Doctors Lounge Membership
Application |
|
|
 |
 |
|
|
|
|
|
|
|
|
send
to a friend
printer
friendly version
