AC/ACMF                                             breast(17,18)
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  adriamycin...... 40 mg/sqm IV day 1.
  cytoxan......... 1 g/sqm IV day 1.
  FREQUENCY....... Repeat cycle every 21 days.

  adriamycin...... 40 mg/sqm IV day 1.
  cytoxan......... 1 g/sqm IV day 1.
  methotrexate.... 30 to 40 mg/sqm IV days 21, 28 and 35.
  fluorouracil.... 400 to 600 mg/sqm IV days 21, 28 and 35.
  FREQUENCY....... Repeat cycle every 42 days.

   17. Boston B, et.al. Combination vs. combination sequential 
       non-hormonal chemotherapy in advanced breast cancer. Proc Am 
       Soc Clin Oncol 17:247, 1976.

  reference...
    Kennealey GT.  Boston B.  Mitchell MS.  Knobf MK.  Bobrow SN.  
    Pezzimenti JF.  Lawrence R.  Bertino JR. Combination 
    chemotherapy for advanced breast cancer: two regimens 
    containing adriamycin. Cancer.  42(1):27-33, 1978 Jul. 
  abstract...
    Forty-eight women with advanced metastatic carcinoma of the 
    breast were treated with one of two combination chemotherapy 
    regimens: 1) adriamycin and cyclophosphamide or 2) adriamycin, 
    cyclophosphamide, methotrexate and 5-fluorouracil. The 
    response rate in the two-drug treatment group was 50% and in 
    the four-drug treatment group, 55%. The median duration of 
    response was ten months in both treatment groups. Dramatic 
    responses were seen in patients with visceral metastases. 
    Patients who responded to chemotherapy had a significantly 
    longer survival than nonresponders (p less than 0.01). The 
    long interval between adriamycin doses (six weeks) in the four 
    drug regimen did not adversely effect the response rate--an 
    important finding in view of the dose-related cardiac toxicity 
    of this agent.