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CAF regimen

Abstract: A comparison of cyclophosphamide, adriamycin, 5-fluorouracil (CAF) and cyclophosphamide, methotrexate, 5-fluorouracil, vincristine, prednisone (CMFVP) in patients with metastatic breast cancer: a Southeastern Cancer Study Group project.

In an ongoing prospective randomized study, 113 evaluable patients have received either a three-drug combination that included cyclophosphamide, Adriamycin and 5-fluorouracil (CAF) or a five-drug combination including cyclophosphamide, methotrexate, 5-fluorouracil, vincristine and prednisone (CMFVP) given intermittently 1 week out of 4. Responses (64%), median duration of response (32 weeks), and median duration of disease control (32 weeks) achieved with CAF were superior to those achieved with CMFVP (37%, 22 weeks, 17 weeks, respectively). Morbidity secondary to CAF was significant, with nausea and vomiting, malaise, total alopecia, and granulocytopenia being the main features.

References
Smalley RV.  Carpenter J.  Bartolucci A.  Vogel C.  Krauss S. A comparison of cyclophosphamide, adriamycin, 5-fluorouracil (CAF) and cyclophosphamide, methotrexate, 5-fluorouracil, vincristine, prednisone (CMFVP) in patients with metastatic breast cancer: a Southeastern Cancer Study Group project. Cancer.  40(2):625-32, 1977 Aug.

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Regimen

Cytoxan......... 500 mg/sqm IV day 1.
Adriamycin...... 50 mg/sqm IV day 1.
Fluorouracil.... 500 mg/sqm IV day 1.
FREQUENCY....... Repeat this cycle every 21 days.

     
  Summary CAF vs CMFVP in metastatic breast cancer
  Response rate 64% vs. 37%
  Median duration of response 32 weeks vs. 22 weeks.
  Toxicity nausea and vomiting, malaise, total alopecia, and granulocytopenia was more significant in the CAF group.
     
   

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Article reviewed by:

Dr. Tamer Fouad, M.D.

 

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