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CAF regimen
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Breast Cancer News |
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Breast Cancer |
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Abstract: A comparison of cyclophosphamide, adriamycin, 5-fluorouracil
(CAF) and cyclophosphamide, methotrexate, 5-fluorouracil, vincristine, prednisone
(CMFVP) in patients with metastatic breast cancer: a Southeastern Cancer
Study Group project.
In an ongoing prospective randomized study,
113 evaluable patients have received either a three-drug combination
that included cyclophosphamide, Adriamycin and 5-fluorouracil (CAF) or a
five-drug combination including cyclophosphamide, methotrexate, 5-fluorouracil,
vincristine and prednisone (CMFVP) given intermittently 1 week out of 4.
Responses (64%), median duration of response (32 weeks), and median duration
of disease control (32 weeks) achieved with CAF were superior to those achieved
with CMFVP (37%, 22 weeks, 17 weeks, respectively). Morbidity secondary
to CAF was significant, with nausea and vomiting, malaise, total alopecia,
and granulocytopenia being the main features.
References
Smalley RV. Carpenter J. Bartolucci A. Vogel C.
Krauss S. A comparison of cyclophosphamide, adriamycin, 5-fluorouracil (CAF)
and cyclophosphamide, methotrexate, 5-fluorouracil, vincristine, prednisone
(CMFVP) in patients with metastatic breast cancer: a Southeastern Cancer
Study Group project. Cancer. 40(2):625-32,
1977 Aug.
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Application |
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| Regimen |
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Cytoxan......... 500 mg/sqm
IV day 1.
Adriamycin...... 50 mg/sqm IV day 1.
Fluorouracil.... 500 mg/sqm IV day 1.
FREQUENCY....... Repeat this cycle every 21 days. |
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Summary |
CAF vs
CMFVP in metastatic breast cancer |
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Response rate |
64% vs. 37% |
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Median duration
of response |
32 weeks vs. 22 weeks. |
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Toxicity |
nausea and
vomiting, malaise, total alopecia, and granulocytopenia was more significant
in the CAF group. |
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