cytoxan......... 400 mg/sqm IV day 1.
methotrexate.... 30 mg/sqm IV days 1 and 8.
fluorouracil.... 400 mg/sqm IV days 1 and 8.
vincristine..... 1 mg IV days 1 and 8.
prednisone...... 20 mg orally four times daily on days 1 to 7.
FREQUENCY....... Repeat cycle every 28 days.
Smalley RV. Carpenter J. Bartolucci A. Vogel C. Krauss S.
A comparison of cyclophosphamide, adriamycin, 5-fluorouracil
(CAF) and cyclophosphamide, methotrexate, 5-fluorouracil,
vincristine, prednisone (CMFVP) in patients with metastatic
breast cancer: a Southeastern Cancer Study Group project.
Cancer. 40(2):625-32, 1977 Aug.
In an ongoing prospective randomized study, 113 evaluable
patients have received either a three-drug combination that
included cyclophosphamide, Adriamycin and 5-fluorouracil (CAF)
or a five-drug combination including cyclophosphamide,
methotrexate, 5-fluorouracil, vincristine and prednisone
(CMFVP) given intermittently 1 week out of 4. Responses (64%),
median duration of response (32 weeks), and median duration of
disease control (32 weeks) achieved with CAF were superior to
those achieved with CMFVP (37%, 22 weeks, 17 weeks,
respectively). Morbidity secondary to CAF was significant,
with nausea and vomiting, malaise, total alopecia, and
granulocytopenia being the main features.