fluorouracil.... 12 mg/kg IV every week times 8 weeks, then
every other week for 7 additional months.
methotrexate.... 0.7 mg/kg/week IV times 8 weeks, then every
other week for 7 months.
vincristine..... 0.035 mg/kg/week IV times 5 weeks, then once
cytoxan......... 2 mg/kg/day orally times 9 months.
prednisone...... 0.75 mg/kg/day orally times 10 days, then one
half times 10 days, then one fourth times 10
days, then 5 mg/day times 20 days, and then
FREQUENCY....... Specified with the drugs above.
Cooper RG. Holland JF. Glidewell O. Adjuvant chemotherapy of
breast cancer. Cancer. 44(3):793-8, 1979 Sep.
One hundred women with primary breast cancer with 4 or more
metastatic axillary nodes were treated for 9 months
postoperatively with vincristine, prednisone,
cyclophosphamide, methotrexate, and fluorouracil (VPCMF).
Sixty-five women have been observed for a minimum of 5 years
or until failure and the rest for 3 years or more. For 73
women who received adjuvant chemotherapy only, observed for 5
1/2 years median, disease-free status by life table analysis
is 68% at 8 years. No significance difference was found
between response of pre- and postmenopausal women in
disease-free interval or survival. Mortality compared to
expectation was sharply reduced; only 9 of 73 have died. These
findings demonstrate the long term effectiveness of relatively
short-term surgical adjuvant combination chemotherapy in pre-
and post-menopausal patients with breast cancer at high risk.