COOPER                                                 breast(24)
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  fluorouracil.... 12 mg/kg IV every week times 8 weeks, then 
                   every other week for 7 additional months.
  methotrexate.... 0.7 mg/kg/week IV times 8 weeks, then every 
                   other week for 7 months.
  vincristine..... 0.035 mg/kg/week IV times 5 weeks, then once 
                   monthly.
  cytoxan......... 2 mg/kg/day orally times 9 months.
  prednisone...... 0.75 mg/kg/day orally times 10 days, then one 
                   half times 10 days, then one fourth times 10 
                   days, then 5 mg/day times 20 days, and then 
                   discontinue.
  FREQUENCY....... Specified with the drugs above.

  reference...
    Cooper RG.  Holland JF.  Glidewell O. Adjuvant chemotherapy of 
    breast cancer. Cancer.  44(3):793-8, 1979 Sep. 
  abstract...
    One hundred women with primary breast cancer with 4 or more 
    metastatic axillary nodes were treated for 9 months 
    postoperatively with vincristine, prednisone, 
    cyclophosphamide, methotrexate, and fluorouracil (VPCMF). 
    Sixty-five women have been observed for a minimum of 5 years 
    or until failure and the rest for 3 years or more. For 73 
    women who received adjuvant chemotherapy only, observed for 5 
    1/2 years median, disease-free status by life table analysis 
    is 68% at 8 years. No significance difference was found 
    between response of pre- and postmenopausal women in 
    disease-free interval or survival. Mortality compared to 
    expectation was sharply reduced; only 9 of 73 have died. These 
    findings demonstrate the long term effectiveness of relatively 
    short-term surgical adjuvant combination chemotherapy in pre- 
    and post-menopausal patients with breast cancer at high risk.