AP                                                  carcinoid(36)
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  adriamycin...... 50 mg/sqm IV day 1.
  cisplatin....... 50 mg/sqm IV day 1 with hydration.
  FREQUENCY....... Repeat cycle every 3 or 4 weeks.

  reference...
    Sridhar KS.  Holland JF.  Brown JC.  Cohen JM.  Ohnuma T. 
    Doxorubicin plus cisplatin in the treatment of apudomas. 
    Cancer.  55(11):2634-7, 1985 Jun 1. 
  abstract...
    Twelve patients with advanced apudomas--six with carcinoid 
    tumors, two with chemodectomas, two with pancreatic islet cell 
    tumor, and one each of medullary carcinoma of the thyroid and 
    paraganglioma of unknown primary--were treated with a 
    combination of doxorubicin 50 mg/m2 and cisplatin 50 mg/m2 
    every 3 to 4 weeks. Biochemical markers were present in 8 of 
    the 12 patients. Five of the 12 patients (3 with carcinoid and 
    2 with chemodectomas) responded with more than 50% regression 
    of tumor size measured as hypothetical area. Three others (two 
    with islet cell tumors and one with carcinoid) had clinical 
    and/or biochemical improvements. A median duration of response 
    was 6 months. Nausea, vomiting, and alopecia were universal. 
    Mild or moderate leukopenia was the most frequent toxicity. No 
    sustained nephrotoxicity was seen. The combination of 
    doxorubicin and cisplatin provides a new palliative therapy 
    for patients with APUD tumors.