ADENOCA cervix(40)
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fluorouracil.... 500 to 800 mg/sqm IV over 76 hours.
adriamycin...... 40 to 50 mg/sqm IV over 76 hours.
cisplatin....... 50 to 60 mg/sqm IV over 76 hours.
FREQUENCY....... Repeat cycle every 28 days.
reference...
Kavanagh JJ. Gershenson D. Copeland L. Roberts WS.
Combination chemotherapy for metastatic or recurrent
adenocarcinoma of the cervix. Journal of Clinical Oncology.
5(10):1621-3, 1987 Oct.
abstract...
Twenty-four patients with recurrent or widespread
adenocarcinoma of the cervix were treated with combination
chemotherapy. The drugs used were 5-fluorouracil (5-FU) (500
to 800 mg/m2), doxorubicin (40 to 50 mg/m2), and cisplatin (50
to 60 mg/m2). The chemotherapy was administered as a 76-hour
continuous infusion via a silastic central venous catheter and
repeated every 28 days. The total response rate was 42% (25%
complete and 17% partial). Median duration of response was 7
months. Areas of response were usually lung and lymph node
metastases. Toxicity, mainly neutropenia, was acceptable. All
patients relapsed. This combination chemotherapy results in a
modest response rate for a malignancy about which there is
little information regarding the treatment of disseminated
disease. Future studies should determine the activity of this
combination administered in a bolus fashion.
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