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Cancer Chemotherapy Regimen for Cervical Cancer


 ADENOCA                                                cervix(40)
 _________________________________________________________________
  fluorouracil.... 500 to 800 mg/sqm IV over 76 hours.
  adriamycin...... 40 to 50 mg/sqm IV over 76 hours.
  cisplatin....... 50 to 60 mg/sqm IV over 76 hours.
  FREQUENCY....... Repeat cycle every 28 days.

  reference...
    Kavanagh JJ.  Gershenson D.  Copeland L.  Roberts WS. 
    Combination chemotherapy for metastatic or recurrent 
    adenocarcinoma of the cervix. Journal of Clinical Oncology.  
    5(10):1621-3, 1987 Oct. 
  abstract...
    Twenty-four patients with recurrent or widespread 
    adenocarcinoma of the cervix were treated with combination 
    chemotherapy. The drugs used were 5-fluorouracil (5-FU) (500 
    to 800 mg/m2), doxorubicin (40 to 50 mg/m2), and cisplatin (50 
    to 60 mg/m2). The chemotherapy was administered as a 76-hour 
    continuous infusion via a silastic central venous catheter and 
    repeated every 28 days. The total response rate was 42% (25% 
    complete and 17% partial). Median duration of response was 7 
    months. Areas of response were usually lung and lymph node 
    metastases. Toxicity, mainly neutropenia, was acceptable. All 
    patients relapsed. This combination chemotherapy results in a 
    modest response rate for a malignancy about which there is 
    little information regarding the treatment of disseminated 
    disease. Future studies should determine the activity of this 
    combination administered in a bolus fashion. 
 
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