BCVM cervix(41)
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bleomycin....... 10 U/sqm/day IV over 7 hours on days 1 to 5.
cisplatin....... 20 mg/sqm/day IV over 7 hours on days 1 to 5.
vincristine..... 1 mg/sqm IV on day 1.
methotrexate.... 40 mg/sqm IV on day 1.
FREQUENCY....... Repeat cycle every 28 days to a maximum of six
courses.
reference...
Rosenthal CJ. Khulpateea N. Boyce J. Mehrotra S. Tamarin
S. Effective chemotherapy for advanced carcinoma of the cervix
with bleomycin, cisplatin, vincristine, and methotrexate.
Cancer. 52(11):2025-30, 1983 Dec 1.
abstract...
This study was designed as a Phase II clinical trial in
advanced recurrent or metastatic squamous cell carcinoma of
the cervix with a combination of bleomycin (B: 10 u/m2/d) and
cisplatin (P: 20 mg/m2/d) administered for five consecutive
days in intravenous infusion for 7 hours and vincristine (V: 1
mg/m2) and methotrexate (M: 40 mg/m2) administered only on day
one of each cycle which was repeated every 28 days up to a
maximum of 6 times. Over a period of 2 years, 15 evaluable
patients with measurable disease received at least 3 courses
of therapy. Six had recurrent disease and nine had distant
metastases. All had previous radiation therapy. There were two
dropouts after the first course due to nausea and vomiting
which was practically universal. Other side effects included:
mild paresthesias of the extremities (89%), stomatitis (41%),
diarrhea (17%), moderate pancytopenia and hypomagnesemia which
was reduced from 65% to 17% when magnesium sulfate 10% was
administered with cisplatin. Sixty-six percent of the
evaluable patients achieved remission (7 partial and 3
complete) usually before the fourth course of therapy. The
disease-free interval was of 29.7 +/- 15 weeks in all
responders (40.6 +/- 15.5 weeks in complete responders). The
mean survival from the start of BPVM therapy was of 55.8 +/-
33.3 weeks in responders and of only 14 +/- 2.9 weeks in
nonresponders (P less than 0.01). It is concluded that BPVM is
an effective combination chemotherapy in advanced squamous
cell carcinoma of the cervix. These results should be
confirmed in a Phase III trial.
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