MBC cervix(44)
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methotrexate.... 30 mg/sqm IV day 1.
bleomycin....... 30 U/day by continuous IV on days 1, 2 and 3.
cisplatin....... 80 mg/sqm IV day 4.
FREQUENCY....... Repeat cycle every 21 days.
reference...
Goldhirsch A. Greiner R. Bleher A. Jeschko M. Dreher E.
Krauer F. Cavalli F. Combination of chemotherapy with
methotrexate, bleomycin, and cis-platinum, and radiation
therapy for locally advanced carcinoma of the cervix. American
Journal of Clinical Oncology. 9(1):12-4, 1986 Feb.
abstract...
Sixteen non-pretreated patients with locally advanced cervical
cancer (FIGO Stage IIIb) were treated with two 3-week cycles
of platinum, bleomycin, and methotrexate (PBM), which were
followed by radiation therapy. Response to both modalities was
seen in 11 patients (69%), and three patients (19%) had a
progression-free survival of more than 2 years. Radiation
therapy was proven to be feasible after two cycles of PBM
combination chemotherapy.
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