COM                                                     colon(45)
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  cytoxan......... 300 mg/sqm IV day 1.
  vincristine..... 1 mg IV day 1.
  methotrexate.... 20 mg/sqm IV day 1.
  FREQUENCY....... Repeat cycle weekly.


  reference...
    Taylor SG 4th.  Desai SA.  DeWys WD. Phase II trial of a 
    combination of cyclosphamide, vincristine, and methotrexate in 
    advanced colorectal carcinoma. Cancer Treatment Reports.  
    62(8):1203-5, 1978 Aug. 
  abstract...
    Twenty patients with advanced colon cancer were treated with a 
    combination of low-dose weekly cyclophosphamide, vincristine, 
    and methotrexate (COM) after demonstrated progression of 
    disease with 5-fluorouracil (5-FU). Four patients (20%) had 
    partial responses with a median survival of 15 months, six 
    (30%) had disease stabilization for 3--16 months (median 
    survival, 8 months), and ten progressed with a median survival 
    of 5.5 months. All four partial responses and five of six 
    stabilizations occurred in patients with a performance status 
    of 0 or 1. COM appeared well-tolerated and at least as 
    effective as alternative secondary chemotherapy following 5-FU 
    failure.