FU-CIS                                                  colon(47)
 _________________________________________________________________
  fluorouracil.... 300 mg/sqm/day by continuous infusion using 
                   ambulatory infusion pump.
  cisplatin....... 20 mg/sqm IV over 20 minutes.
  FREQUENCY....... Repeat cisplatin therapy every 7 days. Continue 
                   therapy for 12 weeks.


  reference...
    Cantrell JE Jr.  Hart RD.  Taylor RF.  Harvey JH Jr. Pilot 
    trial of prolonged continuous-infusion 5-fluorouracil and 
    weekly cisplatin in advanced colorectal cancer. Cancer 
    Treatment Reports.  71(6):615-8, 1987 Jun. 
  abstract...
    Thirty-five patients with previously untreated, advanced, 
    measurable metastatic colorectal carcinoma were treated with a 
    12-week course of continuous 5-fluorouracil (5-FU) and weekly 
    cisplatin. Twenty of 32 evaluable patients responded (five 
    complete and 15 partial responses), for an overall response 
    rate of 63% (90% confidence limits, 43%-75%). Toxicity was 
    generally mild and reversible and included mucositis (40%), 
    painful erythema of the palmar and plantar skin (30%), 
    diarrhea (21%), nausea and vomiting (15%), and leukopenia 
    (6%). One patient died of sepsis secondary to mucositis and 
    myelosuppression. This program is a well-tolerated outpatient 
    regimen for metastatic colorectal carcinoma. The response rate 
    is higher than expected for 5-FU and cisplatin and suggests 
    clinical therapeutic synergism at this dose rate and schedule.