FU-L                                                    colon(48)
 _________________________________________________________________
  fluorouracil.... 600 mg/sqm IV bolus 1 hour after start of 
                   leucovorin.
  leucovorin...... 500 mg/sqm IV over 2 hours.
  FREQUENCY....... Repeat every 7 days and continue for 6 weeks.

  reference...
    Petrelli N.  Herrera L.  Rustum Y.  Burke P.  Creaven P.  
    Stulc J.  Emrich LJ.  Mittelman A. A prospective randomized 
    trial of 5-fluorouracil versus 5-fluorouracil and high-dose 
    leucovorin versus 5-fluorouracil and methotrexate in 
    previously untreated patients with advanced colorectal 
    carcinoma. Journal of Clinical Oncology.  5(10):1559-65, 1987 
    Oct. 
  abstract...
    Seventy-four previously untreated patients with metastatic 
    colorectal adenocarcinoma were prospectively randomized into 
    one of three treatment regimens: (1) 5-fluorouracil (5-FU) 450 
    mg/m2 as an intravenous (IV) bolus daily for five days or 
    toxicity, then 200 mg/m2 IV bolus every other day for six 
    doses; (2) methotrexate (MTX) 50 mg/m2 in normal saline by IV 
    infusion over four hours followed by an IV bolus of 5-FU 600 
    mg/m2. This was administered weekly for 4 weeks and then every 
    2 weeks. (3) Leucovorin 500 mg/m2 in a two-hour IV infusion of 
    normal saline with 5-FU 600 mg/m2 as an IV bolus one hour 
    after the Leucovorin began every week for 6 weeks. The 
    combined complete and partial response rates in the three 
    regimens were 11%, 5%, and 48%, respectively (P = .0009). The 
    median duration of response in the 5-FU and Leucovorin regimen 
    was 10 months. There was no statistically significant 
    difference between the treatment regimens with respect to 
    survival time (P = .6). Toxicity in the 5-FU and Leucovorin 
    regimen was predominantly diarrhea (13 of 30 patients, 40%). 
    In this regimen, eight of 13 patients (52%) who developed 
    diarrhea not only required a dose reduction of 5-FU, but also 
    hospitalization for IV hydration. The predominant toxicity in 
    the 5-FU alone regimen and the 5-FU and MTX regimen was 
    leukopenia. One drug-related death occurred in each regimen.