semustine....... 30 mg/sqm/day orally on days 1 to 5 inclusive.
vincristine..... 1 mg IV day 1 and day 35 (5 weeks).
fluorouracil.... 300 mg/sqm/day IV on days 1 to 5 and on days 35
to 40, inclusive.
streptozotocin.. 500 mg/sqm IV on day 1 and weekly thereafter.
FREQUENCY....... Repeat cycle every 70 days (10 weeks).
Kemeny N. Yagoda A. Braun D Jr. Golbey R. Therapy for
metastatic colorectal carcinoma with a combination of
methyl-CCNU, 5-fluorouracil vincristine and streptozotocin
(MOF-Strep). Cancer. 45(5):876-81, 1980 Mar 1.
Seventy-seven previously untreated patients with measurable
metastatic colorectal carcinoma were treated with a
combination of methyl-CCNU, 5-fluorouracil (5-FU), vincristine
and streptozotocin (MOF-Strep). The treatment schedule
consisted of methyl-CCNU, 30 mg/m2 for 5 consecutive days q 10
weeks; 5-FU, 300 mg/m2 IV for five consecutive days q 5 weeks;
vincristine, 1 mg IV q 5 weeks; and streptozotocin, 500 mg/m2
IV weekly. Two (3%) patients achieved complete remission (CR);
22 (29%) patients, a partial remission (PR); and 13 (18%)
patients, a minor remission (MR). The median duration of
remission was eight months (range, 4-25+months) for patients
obtaining CR/PR status, and six months (range, 4-15 months)
for MR status. The median survival time was 14 months for
patients achieving CR/PR versus seven months for non
responders. Comparison with a previous study of MOF at
Memorial Sloan-Kettering Cancer Center, showed that the
MOF-Strep combination produced a significant (P = 0.004)
increase in the number of complete and partial remissions, 32%
versus 11%, and in survival, 11 versus 9 months, (P = 0.003),