FAP                                                 esophagus(54)
 _________________________________________________________________
  fluorouracil.... 600 mg/sqm IV days 1 and 8.
  adriamycin...... 30 mg/sqm IV day 1.
  cisplatin....... 75 mg/sqm IV day 1 with hydration and mannitol 
                   diuresis.
  FREQUENCY....... Repeat courses every 4 weeks as tolerated.

  reference...
    Gisselbrecht C.  Calvo F.  Mignot L.  Pujade E.  Bouvry M.  
    Danne O. Belpomme D.  Marty M. Fluorouracil (F), Adriamycin 
    (A), and cisplatin (P) (FAP): combination chemotherapy of 
    advanced esophageal carcinoma. Cancer.  52(6):974-7, 1983 Sep 
    15. 
  abstract...
    Twenty-one patients with advanced epidermoid carcinoma of the 
    esophagus were treated with a combination of 5-fluorouracil 
    (F) 600 mg/m2 day 1 and day 8; Adriamycin (A) 30 mg/m2 day 1; 
    and cisplatin (P) 75 mg/m2 day 1 (FAP) with hydration and 
    mannitol-induced diuresis. Each course was repeated every 4 
    weeks. All 21 patients are evaluable for response: 7 patients 
    had an objective response (33%). Two of these responses were 
    complete remissions according to negative endoscopic and 
    pathologic results; five patients had a partial response; all 
    7 responding patients had metastasis prior to treatment. 
    Median survival of the 21 patients was 8 months. Median 
    survival of 9 months for responders is superior to 4.5 months 
    for nonresponders. No severe myelosuppression or 
    nephrotoxicity was observed. This FAP regimen is useful in the 
    treatment of advanced esophageal tumors.