MBC                                                 esophagus(55)
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  methotrexate.... 40 mg/sqm IV days 1 and 14.
  bleomycin....... 10 U IM on days 1, 8, and 15.
  cisplatin....... 50 mg/sqm IV day 4.
  FREQUENCY....... Repeat cycle every 21 days.

  reference...
    Vogl SE.  Greenwald E.  Kaplan BH. Effective chemotherapy for 
    esophageal cancer with methotrexate, bleomycin, and 
    cis-diamminedichloroplatinum II. Cancer.  48(12):2555-8, 1981 
    Dec 15. 
  abstract...
    Ten patients with squamous cancer of the esophagus were 
    treated with an outpatient regimen combining 
    cis-diamminedichloroplatinum (II), methotrexate and bleomycin. 
    Nine of these had metastatic disease or recurrence after 
    radiotherapy. Objective responses were noted in 50%, 
    regardless of performance status or metastatic site. None of 
    three patients with prior radiation therapy responded, 
    however. Median duration of response was six months. 
    Responders survived a median of eight months versus five 
    months for nonresponders. Three patients had severe 
    hematologic toxicity. A single patient with massive disease 
    confined to the esophagus had an excellent response to six 
    weeks of chemotherapy before radical irradiation. He is 
    disease-free after two years but is paraplegic from radiation 
    myelitis. This chemotherapy program is an effective palliative 
    therapy for metastatic esophageal cancer. Its safety and 
    efficacy as part of the initial treatment of local disease 
    should be further investigated.