M-F                                                 esophagus(56)
 _________________________________________________________________
  mitomycin....... 10 mg/sqm IV day 1.
  fluorouracil.... 1,000 mg/sqm/day continuous IV on days 1 to 4 
                   and on days 29 to 32.
  FREQUENCY....... This one cycle is usually followed by surgery 
                   or radiation therapy.

  reference...
    Franklin R.  Steiger Z.  Vaishampayan G.  Asfaw I.  Rosenberg 
    J.  Loh J. Hoschner J.  Miller P. Combined modality therapy 
    for esophageal squamous cell carcinoma. Cancer.  
    51(6):1062-71, 1983 Mar 15. 
  abstract...
    Of 55 patients with esophageal squamous cell carcinoma, 30 
    with localized disease were treated with a combined modality 
    for curative intent. Treatment consisted of mitomycin C (10 
    mg/m2 day 1) and continuous infusion 5-FU (1000 mg/m2 day, 
    days 1-4, 29-32) (CT), radiation (XRT) (3000 rad, days 1-21) 
    with nutritional support, and surgery (days 49-64). Surgery 
    consisted of celiotomy, esophagectomy and esophagogastrostomy 
    +/- postoperative ventilatory support. Postoperative CT plus 
    an additional 2000 rad XRT was restricted to patients with 
    histologic positive tumor. Since five resected patients with 
    subclinical metastatic tumor had an inferior survival equal to 
    25 patients treated essentially for palliation, pretreatment 
    celiotomy seems warranted to identify patients with an 
    inferior prognosis. Of 18 resected patients without 
    disseminated tumor evaluable for this combined modality: six 
    were tumor free, three had intramural and nine transmural 
    tumor; the median survival is 76 weeks and five of six living 
    patients are disease free at 95-190 weeks; and local 
    recurrence occurred in two and in two of seven unresected 
    patients. Since toxicity was minimal except for postoperative 
    pneumonitis (13%) and local recurrence low (13%), two courses 
    of chemotherapy and 5000 rad XRT perhaps obviates the need for 
    resection.