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Cancer Chemotherapy Regimen for Head and Neck Cancer


 CF                                                  head_neck(69)
 _________________________________________________________________
  cisplatin....... 100 mg/sqm IV day 1.
  fluorouracil.... 1,000 mg/sqm/day continuous IV on days 1 to 5.
  FREQUENCY....... Repeat cycle every 3 weeks.

  reference...
    Decker DA.  Drelichman A.  Jacobs J.  Hoschner J.  Kinzie J.  
    Loh JJ.  Weaver A.  Al-Sarraf M. Adjuvant chemotherapy with 
    cis-diamminodichloroplatinum II and 120-hour infusion 
    5-fluorouracil in Stage III and IV squamous cell carcinoma of 
    the head and neck. Cancer.  51(8):1353-5, 1983 Apr 15. 
  abstract...
    A prospective study was carried out to investigate the 
    effectiveness and toxicity of three courses of combination 
    high-dose bolus CDDP and 120-hour continuous infusion 5-FU 
    every three weeks prior to definitive surgery and/or radiation 
    therapy in 35 patients with locally advanced Stage III and IV 
    squamous cell carcinoma of the head and neck. Twenty-two 
    patients (63%) achieved a CR and 11 (31%) a PR after three 
    cycles of chemotherapy, for an objective response rate of 94%. 
    Toxicity was clinically acceptable. Nausea and vomiting 
    occurred in 23 of 35 (66%) without any patients discontinuing 
    therapy for this reason. Leukopenia in 13 (37%) and reversible 
    azotemia in six (17%). Following three courses of 
    chemotherapy, 13 patients had surgical resection and 12 
    patients had radiation therapy. Ten of these 35 patients had 
    no pathologic evidence of cancer in the surgical specimen or 
    preradiation therapy biopsy. Only two patients of those 
    achieving a complete objective response have relapsed. 
    However, the median follow-up has been short. The authors 
    concluded that three courses of CDDP and 5-FU is a highly 
    effective and safe adjuvant treatment in patients with 
    advanced carcinoma of the head and neck. 
 

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