cisplatin....... 100 mg/sqm IV day 1.
fluorouracil.... 1,000 mg/sqm/day continuous IV on days 1 to 5.
FREQUENCY....... Repeat cycle every 3 weeks.
Decker DA. Drelichman A. Jacobs J. Hoschner J. Kinzie J.
Loh JJ. Weaver A. Al-Sarraf M. Adjuvant chemotherapy with
cis-diamminodichloroplatinum II and 120-hour infusion
5-fluorouracil in Stage III and IV squamous cell carcinoma of
the head and neck. Cancer. 51(8):1353-5, 1983 Apr 15.
A prospective study was carried out to investigate the
effectiveness and toxicity of three courses of combination
high-dose bolus CDDP and 120-hour continuous infusion 5-FU
every three weeks prior to definitive surgery and/or radiation
therapy in 35 patients with locally advanced Stage III and IV
squamous cell carcinoma of the head and neck. Twenty-two
patients (63%) achieved a CR and 11 (31%) a PR after three
cycles of chemotherapy, for an objective response rate of 94%.
Toxicity was clinically acceptable. Nausea and vomiting
occurred in 23 of 35 (66%) without any patients discontinuing
therapy for this reason. Leukopenia in 13 (37%) and reversible
azotemia in six (17%). Following three courses of
chemotherapy, 13 patients had surgical resection and 12
patients had radiation therapy. Ten of these 35 patients had
no pathologic evidence of cancer in the surgical specimen or
preradiation therapy biopsy. Only two patients of those
achieving a complete objective response have relapsed.
However, the median follow-up has been short. The authors
concluded that three courses of CDDP and 5-FU is a highly
effective and safe adjuvant treatment in patients with
advanced carcinoma of the head and neck.