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Cancer Chemotherapy Regimen for Head and Neck Cancer


 BMC                                              head_neck(65,66)
 _________________________________________________________________
  bleomycin....... 10 U IM on days 1, 7, and 15.
  methotrexate.... 40 mg/sqm IM on days 1, and 15.
  cisplatin....... 50 mg/sqm IV day 4.
  FREQUENCY....... Repeat cycle every 21 days.

   65. Kaplan BH, et.al. Chemotherapy of advanced cancer of the 
       head and neck with methotrexate, bleomycin and cisplatin in 
       combination. Proc Am Soc Clin Oncol 20:384, 1979.

  reference...
    Kuten A.  Zidan J.  Cohen Y.  Robinson E. Multidrug 
    chemotherapy using bleomycin, methotrexate, and cisplatin 
    alone or combined with radiotherapy in advanced head and neck 
    cancer. Cancer Treatment Reports.  67(6):573-4, 1983 Jun. 
  abstract...
    Twenty-two patients with advanced cancer of the head and neck 
    where treated with a combination of bleomycin, methotrexate, 
    and cisplatin. In ten previously untreated patients, a 
    complete response (CR) rate of 20%, a partial response rate of 
    50%, and a no change rate of 30% were observed. With the 
    addition of radiotherapy, the local CR rate in this group of 
    patients increased to 60%. In 12 patients with recurrent 
    disease after surgery and/or radiotherapy, the CR rate was 
    25%, the partial response rate was 16.7%, and the no change 
    rate was 58.3%. Toxic effects were acceptable, with no 
    fatalities. These short-term results encourage accrual of more 
    patients in the study and further follow-up to determine 
    whether the cure rate can be increased by using cisplatin and 
    radiotherapy in patients with advanced previously untreated 
    head and neck cancer. More energetic treatment should be 
    investigated in patients having disease recurrence after 
    radiotherapy. 
 

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