bleomycin....... 10 U IM on days 1, 7, and 15.
methotrexate.... 40 mg/sqm IM on days 1, and 15.
cisplatin....... 50 mg/sqm IV day 4.
FREQUENCY....... Repeat cycle every 21 days.
65. Kaplan BH, et.al. Chemotherapy of advanced cancer of the
head and neck with methotrexate, bleomycin and cisplatin in
combination. Proc Am Soc Clin Oncol 20:384, 1979.
Kuten A. Zidan J. Cohen Y. Robinson E. Multidrug
chemotherapy using bleomycin, methotrexate, and cisplatin
alone or combined with radiotherapy in advanced head and neck
cancer. Cancer Treatment Reports. 67(6):573-4, 1983 Jun.
Twenty-two patients with advanced cancer of the head and neck
where treated with a combination of bleomycin, methotrexate,
and cisplatin. In ten previously untreated patients, a
complete response (CR) rate of 20%, a partial response rate of
50%, and a no change rate of 30% were observed. With the
addition of radiotherapy, the local CR rate in this group of
patients increased to 60%. In 12 patients with recurrent
disease after surgery and/or radiotherapy, the CR rate was
25%, the partial response rate was 16.7%, and the no change
rate was 58.3%. Toxic effects were acceptable, with no
fatalities. These short-term results encourage accrual of more
patients in the study and further follow-up to determine
whether the cure rate can be increased by using cisplatin and
radiotherapy in patients with advanced previously untreated
head and neck cancer. More energetic treatment should be
investigated in patients having disease recurrence after